We use genetic information to better understand the distribution and causes of diseases and traits, with a focus on body composition, cardiometabolic and neurodegenerative disease, physical activity, as well as other complex traits. Our approaches include:

• Identification and characterization of genetic variants underlying complex human traits and diseases
• Mendelian randomization to assess causal relationships among human traits/diseases
• Genetic admixture associations
• Genetic and environmental influences in disease risk

We use many databases such as the UK Biobank, All of Us Research Program, and NHANES to develop and answer research questions in these areas.