We study nutrient sensing and signal processing in the model organism Saccharomyces cerevisiae (budding yeast). Our main focus is on understanding how the highly conserved TORC1 and PKA pathways regulate and coordinate cell growth and metabolism in response to environmental change.

We approach this problem using high-throughput genetics, quantitative phosphoproteomics, fluorescence microscopy, and other systems biology approaches. By mapping how TORC1 and PKA network components respond across a wide range of conditions and interact with one another, we aim to uncover the circuits cells use to integrate signals and make decisions—a framework likely conserved across eukaryotes.