Selected Publications
Kinnun, J. J., Mallikarjunaiah, K. J., Petrache, H. I., and Brown, M. F. (2015), Elastic Deformation and Area Per Lipid of Membranes: Atomistic View From Solid-State Deuterium NMR Spectroscopy, Biochim. Biophys. Acta 1848, 246–259.
Struts, A. V., Chawla, U., Perera, S. M. D. C., and Brown, M. F. (2015), Investigation of Rhodopsin Dynamics in its Signaling State by Solid-State Deuterium NMR Spectroscopy, in Methods in Molecular Biology, Jastrzebska, B. (Ed.), Springer, in press.
Leftin, A., Molugu, T. R., Job, C., Beyer, K., Brown, M. F. (2014), Area per lipid and cholesterol interactions in membranes from separated local-field 13C NMR spectroscopy, Biophys. J. 107, 2274–2286.
Leioatts, N., Mertz, B., Martínez-Mayorga, K., Romo, T. D., Pitman, M. C., Feller, S. E., Grossfield, A., and Brown, M. F. (2014), Retinal ligand mobility explains internal hydration and reconciles active rhodopsin structures, Biochemistry 53, 376–385.
Xu, X., Struts, A. V., and Brown, M. F. (2014), Generalized Model-Free Analysis of Nuclear Spin Relaxation Experiments, eMagRes 3, 275–286.
Struts, A. V., and Brown, M. F. (2014), Structural Dynamics of Retinal in Rhodopsin Activation Viewed by Solid-State 2H NMR Spectroscopy, in Advances in Biological Solid-State NMR: Proteins and Membrane-Active Peptides, Separovic, F., and Naito, A. (Eds.), The Royal Society of Chemistry, Cambridge, pp. 320–352.
Leftin, A., Xu, X., and Brown, M. F. (2014), Phospholipid Bilayer Membranes: Deuterium and Carbon-13 NMR Spectroscopy, eMagRes 3, 199–214.
Zhu, S., Brown, M. F., Feller, S. E. (2013), Retinal Conformation Governs pKa of Protonated Schiff Base in Rhodopsin Activation, J. Am. Chem. Soc. 135, 9391−9398.
Zook, J. D., Molugu, T. R., Jacobsen, N. E., Lin, G., Soll, J., Cherry, B. R., Brown, M. F., and Fromme, P. (2013), High-Resolution NMR Reveals Secondary Structure and Folding of Amino Acid Transporter from Outer Chloroplast Membrane, PLoS ONE 8, e78116–e78116.
Leftin, A., Job, C., Beyer, K., and Brown, M. F. (2013), Solid-state 13C NMR Reveals Annealing of Raft-Like Membranes Containing Cholesterol by the Intrinsically Disordered Protein a-Synuclein, J. Mol. Biol. 425, 2973–2987.
Struts, A. V., and Brown, M. F. (2013), Activation of Rhodopsin Based on Solid-State NMR Spectroscopy, in Encyclopedia of Biophysics, Roberts, G. C. K. (Ed.), Springer-Verlag, Heidelberg, pp. 2231–2243.
Kinnun, J. J., Leftin, A., and Brown, M. F. (2013), Solid-State NMR Spectroscopy for the Undergraduate Physical Chemistry Laboratory, J. Chem. Ed. 90, 123−128.
Brown, M. F. (2012), Curvature Forces in Membrane Lipid-Protein Interactions, Biochemistry 51, 9782−9795.
Brown, M. F. (2012), UV–Visible and Infrared Methods for Investigating Lipid–Rhodopsin Membrane Interactions, in Methods in Molecular Biology, Klein-Seetharaman, J., and Nagarajan, V. (Eds.), Springer, pp. 127–153.
Mertz, B., Struts, A. V., Feller, S. E., and Brown, M. F. (2012), Molecular Simulations and Solid-State NMR Investigate Dynamical Structure in Rhodopsin Activation, Biochim. Biophys. Acta 1818, 241–251.
Olausson, B. E. S., Grossfield, A., Pitman, M. C., Brown, M. F., Feller, S. E., and Vogel, A. (2012), Molecular Dynamics Simulations Reveal Specific Interactions of Posttranslational Palmitoyl Modifications with Rhodopsin in Membranes, J. Am. Chem. Soc. 134, 4324−4331.
Struts, A. V., Salgado, G. F. J., Martínez-Mayorga, K., and Brown, M. F. (2011), Retinal dynamics underlie its switch from inverse agonist to agonist during rhodopsin activation, Nature Struct. Mol. Biol. 18, 392-394.
Mertz, B., Lu, M., Brown, M. F., and Feller, S. E. (2011), Steric and Electronic Influences on the Torsional Energy Landscape of Retinal, Biophys. J. 101, L17-L19.
Struts, A. V., Salgado, G. F. J., and Brown, M. F. (2011), Solid-State 2H NMR Relaxation Illuminates Functional Dynamics of Retinal Cofactor in Membrane Activation of Rhodopsin, Proc. Natl. Acad. Sci. U.S.A. 108, 8263-8268.
Leftin, A., and Brown, M. F. (2011), An NMR Data Base for Simulations of Membrane Dynamics, Biochim. Biophys. Acta 1808, 818-839.
Mallikarjunaiah, K. J., Leftin, A., Kinnun, J. J., Justice, M. J., Rogozea, A. L., Petrache, H. I., and Brown, M. F. (2011), Solid-State 2H NMR Demonstrates Correspondence of Hydrostatic and Osmotic Pressures in Lipid Membrane Deformation, Biophys. J. 100, 98-107.
Bartels, T., Ahlstrom, L. S., Leftin, A., Kamp, F., Haass, C., Brown, M. F., and Beyer, K. (2010), The N-Terminus of a-Synuclein Triggers Membrane Binding and Helix Folding, Biophys. J. 99, 1-9.
Brown, M. F., Salgado, G. F. J., Struts, A. V. (2010), Retinal Dynamics During Light Activation of Rhodopsin Revealed by Solid-State NMR Spectroscopy, Biochim. Biophys. Acta 1798, 177-193.
Zaitseva, E., Brown, M. F., and Vogel, R. (2010), Sequential Rearrangement of Interhelical Networks Upon Rhodopsin Activation in Membranes: The Meta IIa Conformational Substate, J. Am. Chem. Soc. 132, 4815-4821.