Lipid Membrane Biophysics

  • Biophysics of Membrane Stiffening by Cholesterol and Phosphatidylinositol 4,5-bisphosphate (PIP2) ; 2023 ;Doole, F.T., Gupta, S., Kumarage, T., Ashkar, R., Brown, M.F. (2023). Biophysics of Membrane Stiffening by Cholesterol and Phosphatidylinositol 4,5-bisphosphate (PIP2). In: Dantsker, A.R. (eds) Cholesterol and PI(4,5)P2 in Vital Biological Functions. Advances in Experimental Medicine and Biology, 1422. Springer, Cham. https://doi.org/10.1007/978-3-031-21547-6_2
  • Molecular simulations and NMR reveal how lipid fluctuations affect membrane mechanics ; 2023 ;Milka Doktorova, George Khelashvili, Rana Ashkar and Michael F. Brown, (2023) Bio Phys. J. 122, 984-1002, https://doi.org/10.1016/j.bpj.2022.12.007 View Publication
  • Cholesterol stiffening of lipid membranes and drug interactions: Insights from neutron spin echo and deuterium NMR spectroscopy ; 2022 ;Chapter 29 Sudipta Gupta. Fathima T. Doole, Teshani Kumarage, Milka Doktorova, George Khelashvili, Rana Ashkar, Michael F. Brown (2022), Academic Press, Cholesterol From Chemistry and Biophysics to the Clinic, 771-796, https://doi.org/10.1016/B978-0-323-85857-1.00037-7 View Publication[edit]
  • Cholesterol Stiffening of Lipid Membranes ; 2022 ;Fathima T Doole, Teshani Kumarage, Rana Ashkar, Michael F Brown, J Membr Biol. 2022, 255(4-5):385-405. doi: https://doi.org/10.1007/s00232-022-00263-9. View Publication
  • Phospholipid headgroups govern area per lipid and emergent elastic properties of bilayers ; 2022 ;Trivikram R. Molugu, Robin L. Thurmond, Todd M. Alam, Theodore P. Trouard, and Michael F. Brown (2022) Bio phys J. 121, 4205-4220, https://doi.org/10.1016/j.bpj.2022.09.005View Publication[edit]
  • How cholesterol stiffens unsaturated lipid membranes ; 2020 ;Saptarshi Chakraborty, Milka Doktorova, Trivikram R. Molugu, Frederick A. Heberle, Haden L. Scott, Boris Dzikovski, Michihiro Nagao, Laura-Roxana Stingaciu, Robert F. Standaert, Francisco N. Barrera, John Katsaras, George Khelashvili, Michael F. Brown, and Rana Ashkar View Publication
  • Collective dynamics in lipid membranes ; 2019 ;Brown, M. F. (2019) In Mu-Ping Nieh, Frederick A. Heberle, John Katsaras (Eds.), Characterization of Biological Membranes: Structure and Dynamics (pp. 231–268). Berlin, Boston: De Gruyter.View Publication
  • Cholesterol Effects on the Physical Properties of Lipid Membranes Viewed by Solid-state NMR Spectroscopy ; 2019 ;Molugu T.R., Brown M.F. (2019)  In: Rosenhouse-Dantsker A., Bukiya A. (eds) Cholesterol Modulation of Protein Function.  Adv. Exp. Med. Biol., 1115, 99-133.View Publication[edit]
  • Flexible lipid nanomaterials studied by NMR spectroscopy ; 2019 ;Mallikarjunaiah, K.J., Kinnun, J.J., Petrache, H.I., Brown, M.F. (2019) Phys. Chem. Chem. Phys.  21, 18422–18457View Publication[edit]
  • Solid-State 2H NMR Studies of Water-Mediated Lipid Membrane Deformation ; 2018 ;Molugu T.R., Xu X., Lee S., Mallikarjunaiah K.J., Brown M.F. (2018)  In: Webb G. (eds) Modern Magnetic Resonance. Springer, ChamView Publication[edit]
  • Cholesterol-induced suppression of membrane elastic fluctuations at the atomistic level ; 2016 ;Molugu, T. R., Brown M. F. (2016) Chem. Phys. Lipids, 199, 39-51 View Publication[edit]
  • Elastic Deformation and Area Per Lipid of Membranes: Atomistic View From Solid-State Deuterium NMR Spectroscopy ; 2015 ;Kinnun, J. J., Mallikarjunaiah, K. J., Petrache, H. I., and Brown, M. F. (2015), Biochim. Biophys. Acta 1848, 246–259View Publication[edit]
  • Area per lipid and cholesterol interactions in membranes from separated local-field 13C NMR spectroscopy ; 2014 ;Leftin, A., Molugu, T. R., Job, C., Beyer, K., Brown, M. F. (2014),Biophys. J. 107, 2274–2286.View Publication[edit]
  • Solid-State 2H NMR Demonstrates Correspondence of Hydrostatic and Osmotic Pressures in Lipid Membrane Deformation ; 2011 ;Mallikarjunaiah, K. J., Leftin, A., Kinnun, J. J., Justice, M. J., Rogozea, A. L., Petrache, H. I., and Brown, M. F., Biophys. J. 100, 98-107.View Publication[edit]
  • Phase Separation in Binary Mixtures of Bipolar and Monopolar Lipid Dispersions Revealed by 2H NMR Spectroscopy, Small Angle X-Ray Scattering, and Molecular Theory ; 2009 ;Brownholland, D., Longo, G. S., Struts, Matthew J., Justice, M. J., Szleifer, I., Petrache, H. I., Brown, M. F., Thompson, D. H., Biophys. J. 97, 2700-2709.View Publication[edit]
  • Bolalipid Membrane Structure Revealed by Solid-State 2H NMR Spectroscopy ; 2008 ;Holland, D. P., Struts, A. V., Brown, M. F., and Thompson, D. H., J. Am. Chem. Soc. 130, 4584–4585.View Publication[edit]
  • Raft–like Mixtures of Sphingomyelin and Cholesterol Investigated by Solid-State 2H NMR Spectroscopy ; 2008 ;Bartels, T., Bittman, R., Beyer, K., and Brown, M. F., J. Am. Chem. Soc. 44, 14521-14532.View Publication[edit]
  • X-ray Scattering and Solid-State 2H NMR Probes of Structural Fluctuations in Lipid Membranes ; 2007 ;Petrache, H. I., and Brown, M. F., in Methods in Membrane Lipids, Dopico, A. (Ed.), Humana Press, Totowa, pp. 339-351View Publication[edit]
  • Packing and Elasticity of Polyunsaturated w-3 and w-6 Phospholipids as Determined by 2H NMR Spectroscopy and X-Ray Diffraction ; 2005 ;Rajamoorthi, K., Petrache, H. I., McIntosh, T. J., and Brown, M. F., J. Am. Chem. Soc. 127, 1576–1588.View Publication[edit]
  • Anisotropic Motion and Molecular Dynamics of Cholesterol, Lanosterol, and Ergosterol in Lecithin Bilayers Studied by Quasi-elastic Neutron Scattering ; 2002 ;Endress, E., Heller, H., Casalta, H., Brown, M. F., and Bayerl, T. M., Biochemistry 41, 13078-13086.View Publication[edit]
  • Structural Properties of Docosahexaenoyl Phospholipid Bilayers Investigated by Solid-State 2H NMR Spectroscopy ; 2001 ;Petrache, H. I., Salmon, A. S., and Brown, M. F., J. Am. Chem. Soc. 123, 12611-12622.View Publication[edit]
  • Softening of Membrane Bilayers by Detergents Elucidated by Deuterium NMR Spectroscopy ; 2000 ;Otten, D., Brown, M. F., and Beyer, K., J. Phys. Chem. B 104, 12119-12129.View Publication[edit]
  • Area per Lipid and Acyl Length Distributions in Fluid Phosphatidylcholines Determined by 2H NMR Spectroscopy ; 2000 ;Petrache, H. I., Dodd, S. W., and Brown, M. F., Biophys. J. 79, 3172-3192.View Publication[edit]
  • 2H-NMR in Liquid Crystals and Membranes ; 1999 ;Brown, M. F., and Nevzorov, A. A., Colloids and Surfaces 158, 281-298View Publication[edit]
  • Structure and Packing of Phosphatidylcholines in Lamellar and Hexagonal Liquid Crystalline Mixtures with a Nonionic Detergent: A Wide Line NMR Study ; 1994 ;Thurmond, R. L., Otten, D., Brown, M. F., and Beyer, K., J. Phys. Chem. 98, 972-983.View Publication[edit]
  • Order, and Dynamics of Lipid Hexagonal Phases Studied by Deuterium NMR Spectroscopy ; 1993 ;Thurmond, R. L., Lindblom, G., and Brown, M. F., Biochemistry 32, 5394-5410.View Publication
  • Deuterium NMR Study of Intermolecular Interactions in Lamellar Phases Containing Palmitoyllysophosphatidycholine ; 1992 ;Jansson, M., Thurmond, R. L., Barry, J. A., and Brown, M. F., J. Phys. Chem. 96, 9532-9544.View Publication[edit]
  • The Photoinduced Destabilization of Liposomes ; 1992 ;Lamparski, H., Liman, U., Barry, J. A., Frankel, D. A., Ramaswami, V., Brown, M. F., and O’Brien, D. F., Biochemistry 31, 685-694.View Publication[edit]
  • 31P NMR and X-Ray Diffraction Study of the Effect of Photopolymerization on Lipid Polymorphism ; 1992 ;Barry, J. A., Lamparski, H., Shyamsunder, E., Osterberg, F., Cerne, J., Brown, M. F., and O’Brien, D. F., Biochemistry 31, 10114-10120.View Publication[edit]
  • Bilayers of Arachidonic Acid Containing Phospholipids Studied by 2H and 31P NMR Spectroscopy ; 1991 ;Rajamoorthi, K., and Brown, M. F., Biochemistry 30, 4204-4212.View Publication[edit]
  • Effect of Bile Salts on Monolayer Curvature of a Phosphatidylethanolamine/Water Model Membrane System ; 1991 ;Thurmond, R. L., Lindblom, G., and Brown, M. F., Biophys. J. 60, 728-732.View Publication[edit]
  • Molecular Areas of Phospholipids as Determined by 2H NMR Spectroscopy: Comparison of Phosphatidylethanolamines and Phosphatidylcholines ; 1991 ;Thurmond, R. L., Dodd, S. W., and Brown, M. F., Biophys. J. 59, 108-113.View Publication[edit]
  • Low Temperature 2H NMR Spectroscopy of Phospholipid Bilayers Containing Docosahexaenoyl (22:6w3) Chains ; 1991 ;Barry, J. A., Trouard, T. P., Salmon, A., and Brown, M. F., Biochemistry 30, 8386-8394.View Publication[edit]
  • Magnetic Alignment and Orientational Order of Dipalmitoylphosphatidylcholine Bilayers Containing Palmitoyllyso-phosphatidylcholine ; 1990 ;Jansson, M., Thurmond, R. L., Trouard, T. P., and Brown, M. F., Chem. Phys. Lipids 54, 157-170.View Publication[
  • Influences of Membrane Curvature in Lipid Hexagonal Phases Studied by Deuterium NMR Spectroscopy ; 1990 ;Thurmond, R. L., Lindblom, G., and Brown, M. F., Biochem. Biophys. Res. Commun. 173, 1231-1238.View Publication
  • Deuterium NMR Spectroscopy of Saturated and Polyunsaturated Lipid Bilayers ; 1989 ;Brown, M. F., Dodd, S. W., and Salmon, A., in Highlights of Modern Biochemistry (Kotyk, A., et al., Eds.) VSP International, Zeist, pp. 725-734.View Publication
  • Configurational Statistics of Acyl Chains in Polyunsaturated Lipid Bilayers from 2H NMR ; 1987 ;Salmon, A., Dodd, S. W., Williams, G. D., Beach, J. M., and Brown, M. F., J. Am. Chem. Soc. 109, 3600-2609.View Publication
  • Membrane NMR: A Dynamic Research Area ; 1985 ;Brown, M. F., and Williams, G. D., J. Biochem. Biophys. Meth. 11, 71-81.View Publication[edit]
  • 14N NMR of Lipid Bilayers: Effects of Ions and Anesthetics ; 1984 ;Siminovitch, D. J., Brown, M. F., and Jeffrey, K. R., Biochemistry 23, 2412-2420.View Publication
  • Influence of Cholesterol on the Polar Region of Phosphatidylcholine and Phosphatidylethanolamine Bilayers ; 1978 ;Brown, M. F., and Seelig, J., Biochemistry 17, 381-384.View Publication
  • Ion-Induced Changes in Head Group Conformation of Lecithin Bilayers ; 1977 ;Brown, M. F., and Seelig, J., Nature 269, 721-723.View Publication