Independent Publications and Patents:
more coming soon…..
119) Bao, J.; Kang, K.-S.; Molineux, J.; Bischoff, D. J.; Mackay, M. E.; Pyun, J.; Njardarson, J. T. “Dithiophosphoric Acids for Polymer Functionalizations” Angew. Chem. Int. Ed. 2024, 63, e202315963.
118) Olikagu, C.; Kumirov, V. K.; Njardarson, J. T.; Hahn, M. J.; Pyun, J. P. “NMR Spectroscopic Characterization of Polyhalodisulfides via Sulfenyl Chloride Inverse Vulcanization with Sulfur Monochloride” Polymer 2024, 290, 126539.
117) Bao, J.; Nick, S. J.; Lanin, A. S.; Iragorri Molinero, N.; Sera, Brendon; Njardarson, J. T. “Stereoselective Synthesis of Conjugated Di- and Trienamides via a Dienolate Enabled Anionic Cascade” J. Org. Chem. 2023, 88, 17845-17488.
116) Qureshi, M. H.; Bao, J.; Kleine, T. S.; Kim, K.-J.; Carothers, K. J.; Molineux, J.; Cho, E.; Lee, T.; Kang, K.-S.; Godman, N.; Coropceanu, V.; Bredas, J.-L.; Norwood, R. B.; Njardarson, J. T.; Pyun, J. “Synthesis of Deuterated & Sulfurated Polylmers by Inverse Vulcanization: Engineering Infrared Transparency via Deuteration” J. Am. Chem. Soc. 2023, 145, 27821-27829.
115) Njardarson, J. T. “Introductory Organic Chemistry (1st Semester) for Blind and Visually Impaired Students: Practical Lessons and Experiences” J. Chem. Ed. 2023, 100,3960-3967.
114) Delost, M. D.; Njardarson, J. T. “Synthesis of Oxiranes and Aziridines from Aldehydes and Imines Using Anionic Homologation Approaches” a book chapter in “Homologation Reactions: Reagents, Applications and Mechanisms” Wiley, 2023 (Editor: Vittorio Pace).
113) Bao, J.; Martin, K. P.; Cho, E.; Kang, K.-S.; Glass, R. S.; Coropceanu, V.; Bredas, J.-L.; Parker, W. O’Neil.; Njardarson, J. T.; Pyun, J. “On the Mechanism of the Inverse Vulcanization of Elemental Sulfur: Structural Characterization of Poly(sulfur-random-(1,3-diisopropenylbenzene))” J. Am. Chem. Soc. 2023, 145, 12386-12397.
112) Groch, J. R.; Lauta, N. R.; Njardarson, J. T. “One Step Selective Counterion Dependent Formation of Conjugated Chiral N-Sulfinylimines from Aldehydes” Org. Lett. 2023, 25, 395-399.
111) Pyun, D. C.; Norwood, R.; Njardarson, J. T.; Kang, K.-S.; Glass, R.; Lee, T.; Olikagu, C.; Carothers, K. “Polymers Obtained from Unsaturated Compounds and Sulfur Halides” WO2023043737 issued March 23rd 2023.
110) Pyun, D. C.; Norwood, R.; Njardarson, J. T.; Glass, R.; Lee, T.; Olikagu, C.; Kang, K.-S. “Flame Retardant Polymers and Processes for Producing and Using the Same” WO2023043735 issued March 23rd 2023.
109) Kang, K.-S.; Olikagu, C.; Lee, T.; Bao, J.; Molineux, J.; Holmen, L. N.; Martin, K. P.; Kim, K.-J.; Kim, K.-H.; Bang, J.; Kumirov, V. K.; Glass, R. S.; Norwood, R. B.; Njardarson, J. T.; Pyun, J. “Sulfenyl Chlorides: An Alternative Monomer Feedstock from Elemental Sulfur for Polymer Synthesis” J. Am. Chem. Soc. 2022, 144, 23044-23052.
108) Qureshi, M. H.; Njardarson, J. T.; “Anionic Amino-Cope Rearrangement Cascade Synthesis of 2,4-Subsituted Benzoate Esters from Acyclic Building Blocks” Org. Lett. 2022, 24, 7978-7982.
107) Scott, K. A.; Groch, J. R.; Bao, J.; Marshall, C. M.; Allen, R. A.; Nick, S. J.; Lauta, N. R.; Williams, R. E.; Qureshi, M. H.; Delost, M. D.; Njardarson, J. T.; “Minimalistic Graphical Presentation Approach for Total Syntheses” Tetrahedron, 2022, 126, 133062.
106) Scott, K. A.; Cox, P. B.; Njardarson, J. T. “Phenols and Pharmaceuticals. Analysis of a Recurring Motif” J. Med. Chem. 2022, 65, 7044-7072.
105) Lee, T.; Dirlam, P. T.; Njardarson, J. T.; Glass, R. S.; Pyun, J. “Polymerizations with Elemental Sulfur: From Petroleum Refining to Polymeric Materials” J. Am. Chem. Soc. 2022, 144, 5-22.
104) Delost, M. D.; Njardarson, J. T. “Oxiranes and Oxirenes – Monocyclic”, Comprehensive Heterocyclic Chemistry IV: Section 1, Chapter 1.03. 2022, 199-274.
103) Aspinwall, C.; Mohktari, Z.; Njardarson, J. T.; Janczak, C.; Scott, K. “Nanocomposite Particles Comprising a Boronic Acid Moiety and Methods for Producing and Using the Same” US Patent 20220381789 issued December 1st 2022.
102) Aspinwall, C.; Mohktari, Z.; Njardarson, J. T.; Janczak, C.; Scott, K. “Nanocomposite Particles Comprising a Boronic Acid Moiety and Methods for Producing and Using the Same” WO2022231604 issued November 3rd 2022.
101) Njardarson, J. T.; Chogii, I.; Smith, D. T.; Vitaku, E.; Zarnescu, D. C.; Allen, R. “Neuroprotective Compounds and Methods of their Preparation and use for Treating Neurodegenerative Diseases and Conditions” US Patent 20220031659 issued February 3rd 2022.
100) Delost, M. D.; Njardarson, J. T. “Mild Darzens Annulations for Assembly of Trifluorothiomethylated (SCF3) Aziridine and Cyclopropane Structures” Org. Lett. 2021, 23, 6121-6125.
99) Lauta, N. R.; Williams, R. E.; Smith, D. T.; Njardarson, J. T. “Oxidative Route to Indoles via Amino-Hydroxylation of ortho-Allenyl Anilines” J. Org. Chem. 2021, 86, 10713-10723.
98) Scott, K. A.; Groch, J. R.; Chogii, I.; Delost, M. D.; Das, P.; Njardarson, J. T. “Dienolate Annulation Approach for Assembly of Densely Substituted Aromatic Architectures” J. Org. Chem. 2021, 86, 10555-10555.
97) Das, P.; Delost, M. D.; Qureshi, M. H.; Bao, J.; Fell, J. S.; Houk, K. N.; Njardarson, J. T. “Dramatic Effect of g-Heteroatom Dienolate Substituents on Counterion Assisted Asymmetric Anionic Amino-Cope Reaction Cascades” J. Am. Chem. Soc. 2021, 143, 5793-5804.
96) Scott, K. A.; Qureshi, M. H.; Cox, P.; Marshall, C. M.; Stuart, B. A. R.; Wilcox, M.; Njardarson, J. T. “A Structural Analysis of the FDA Green Book-Approved Veterinary Drugs and Select Roles in Human Medicine” J. Med. Chem. 2020, 63, 15449-15482.
95) Delost, M. D.; Njardarson, J. T. “Strategic Vinyl Sulfone Nucleophile b-Substitution Significantly Impacts Selectivity in Vinylogous Darzens and aza-Darzens Reactions” Org. Lett. 2020, 22, 6917-6921.
94) Chogii, I.; Das, P.; Njardarson, J. T. “Efforts toward a Unified Kainoid Family Synthesis Approach: Unexpected Sulfinamide Directed Conjugate Addition Results” Asian. J. Org. Chem. 2019, 8, 1041-1044.
93) Das, P.; Delost, M. D.; Qureshi, M. H.; Smith, D. T.; Njardarson, J. T. “A Survey of the Structures of US FDA Approved Combination Drugs” J. Med. Chem. 2019, 62, 4265-4311.
92) Njardarson, J. T.; Chogii, I.; Smith, D. T.; Vitaku, E.; Zarnescu, D. C. “Neuroprotective Compounds and Methods of use for Treating Neurodegenerative Diseases and Conditions” US Patent 20190350902 issued November 21st 2019.
91) Delost, M. D.; Smith, D. T.; Anderson, B. J.; Njardarson, J. T. “From Oxiranes to Oligomers: Architectures of US FDA Approved Pharmaceuticals Containing Oxygen Heterocycles” J. Med. Chem. 2018, 61, 10996-11020.
90) Chogii, I.; Das, P.; Delost M. D.; Crawford, M. N.; Njardarson, J. T. “Asymmetric Vinylogous aza-Darzens Approach to Vinyl Aziridines” Org. Lett. 2018, 20, 4942-4945.
89) Smith, B. R.; Njardarson, J. T. “Review of Synthetic Approaches toward Maoecrystal V” Org. Biomol. Chem. 2018, 16, 4210-4222.
88) Smith, B. R.; Njardarson, J. T. “[2.2.2] to [3.2.1]-Bicycle Rearrangement Approach to the Gibberellin Family of Natural Products” Org. Lett. 2018, 20,2993-2996.
87) Scott, K. A.; Njardarson, J. T. “Analysis of US FDA-Approved Drugs Containing Sulfur Atoms” Topics in Current Chemistry – Sulfur Chemistry, 2018, 376, 1-34.
86) Smith, B. R.; Njardarson, J. T. “Double-Diels-Alder Approach to Maeocrystal V. Unexpected C-C Bond-Forming Fragmentations of the [2.2.2]-Bicyclic Core” Org. Lett. 2017, 19, 5316-5319.
85) Chogii, I.; Das, P.; Fell, J. S.; Scott, K. A.; Crawford, M. N.; Houk, K. N.; Njardarson, J. T. “New Class of Anion-Accelerated Amino-Cope Rearrangement as Gateway to Diverse Chiral Structures” J. Am. Chem. Soc. 2017, 139, 13141-13146.
84) Smith, D. T.; Vitaku, E.; Njardarson, J. T. “Dearomatization Approach to 2-Trifluoromethylated Benzofuran and Dihydrobenzofuran Products” Org. Lett. 2017, 19, 3508-3511.
83) Njardarson, J. T.; Chogii, I. “Organic Reactions to Prepare Aziridines and Dihydrofurans Utilizing an a,b-Unsaturated Compound” WO2017011418 issued January 19th 2017.
82) Vitaku, E.; Njardarson, J. T. “Mild Meta-Selective Alkylation of Catechol Mono-Ethers” Eur. J. Org. Chem. 2016,3679-3683.
81) Das, P.; Njardarson, J. T. “Anionic Cascade Routes to Sulfur and Nitrogen Heterocycles Originating from Thio- and Aminophosphate Precursors” Eur. J. Org. Chem. 2016,4249-4259.
80) Vitaku, E.; Smith, D. T.; Njardarson, J. T. “Metal-Free Synthesis of Fluorinated Indoles Enabled by Oxidative Dearomatization” Angew. Chem. Int. Ed. 2016, 55, 2243-2247.
79) Njardarson, J. T.; Smith, D. T.; Vitaku, E. “Methods and System for Drug Design and Drug Screening” US Patent 20160042156 issued February 11th 2016.
78) Njardarson, J. T.; Chogii, I.; Smith, D. T.; Vitaku, E. “Organic Reactions to Prepare Pyrrolines and Other Related Compounds” WO2016014426 issued January 28th 2016.
77) Njardarson, J. T.; Isoe, J.; Miesfeld, R. “Thiopyrano[3,4-e]isoindolediones as Mosquitocides and Methods of Making and Using Thereof” WO2016007913 issued January 14th 2016.
76) Chogii, I.; Njardarson, J. T. “Asymmetric [3+2] Annulation Approach to 3-Pyrrolines. Concise Total Syntheses of (-)-Supinidine, (-)-Isoretronecanol and (+)-Elacomine” Angew. Chem. Int. Ed. 2015, 54, 13706-13710.
75) Das, P.; Njardarson, J. T. “Synthesis of 1,2,3,6-Tetrahydropyridines via Aminophosphate Enabled Anionic Cascade and Acid Catalyzed Cyclization Approaches” Org. Lett. 2015, 17, 4030-4033.
74) Draghici, C.; Njardarson, J. T. “Synthetic Approaches and Total Syntheses of Vinigrol, A Unique Diterpenoid” Tetrahedron 2015, 71,3775-3793.
73) Smith, D. T.; Njardarson, J. T. “Ring Expansions of Oxiranes and Oxetanes” Topics in Heterocyclic Chemistry 2015, 41, 281-309.
72) Vitaku, E.; Njardarson, J. T. “Formation of Fused Aromatic Architectures via an Oxidative Dearomatization – Radical Cyclization Rearomatization Approach” Tetrahedron Lett. 2015, 56, 3550-3552.
71) Draghici, C.; Njardarson, J. T. “The Realization of an Oxidative Dearomatization-Intramolecular Diels-Alder Route to Vinigrol” Strategies and Tactics in Organic Synthesis 11 2015, 335-376.
70) Smith, B. R.; Eastman, C. M.; Njardarson, J. T. “Beyond C, H, O and N! Analysis of the Elemental Composition of US FDA Approved Drug Architectures” J. Med. Chem. 2014, 57, 9764-9773.
69) Vitaku, E.; Smith, D. T.; Njardarson, J. T. “Analysis of the Structural Diversity, Substitution Patterns and Frequency of Nitrogen Heterocycles among US FDA Approved Pharmaceuticals” J. Med. Chem. 2014, 57, 10257-10274.
68) Guo, B.; Vitaku, E.; Njardarson, J. T. “Mild Stereoselective Formation of Tri- and Tetrasubstituted Olefins by Regioselective Ring Opening of 1,1-Disubstituted Vinyl Oxiranes with Dialkyl Dithiophosphates” Tetrahedron Lett. 2014, 55, 3232-3234.
67) Smith, D. T.; Njardarson, J. T. “A Scalable Rhodium Catalyzed Intermolecular Rhodium Aziridination Reaction” Angew. Chem. Int. Ed. 2014, 53, 4278-4280.
66) Ilardi, E. A.; Vitaku, E.; Njardarson, J. T. “Data Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals to Reveal Opportunities for Drug Design and Discovery” J. Med. Chem. 2014, 57, 2832-2842.
65) Yang, Q.; Draghici, C.; Njardarson, J. T.; Li, F.; Smith, B. R.; Das, P. “Oxidative Dearomatization Enabled Total Synthesis of Vinigrol” Org. Biomol. Chem. 2014, 12, 330-344.
64) Scheinberg, D. A.; McDewitt, M. R.; Antczak, C.; Chattopadhyay, D.; May, R.; Njardarson, J. T.; Phillips, M. R. “Self-Assembling Single Wall Nanotube Constructs Functionalized with Targeting Moieties/Payload Mols./Peptides/Oligonucleotides/Enzymes and Thereapeutic Uses Thereof” US Patent 20140086831 issued March 27th 2014.
63) Yang, Q.; Njardarson, J. T. “Base Mediated Deprotection Strategies for Trifluoroethyl Ether (TFEE), a New Alcohol Protecting Group” Tetrahedron. Lett. 2013, 54, 7080-7082.
62) Guo, B.; Njardarson, J. T. “Z-Selective Ring Opening of Vinyl Oxetanes with Dialkyl Dithiophosphate Nucleophiles” Chem. Commun. 2013, 49, 10802-10804.
61) Ilardi, E. A.; Njardarson, J. T. “Ring Expansions of Vinyloxiranes, -thiiranes and -aziridines: Synthetic Approaches, Challenges and Catalytic Success Stories” J. Org. Chem. 2013, 78, 9533-9540.
60) Yang, Q.; Njardarson, J. T.; Draghici, C.; Li, F. “Total Synthesis of Vinigrol” Angew. Chem. Int. Ed. 2013, 52, 8648-8651.
59) Ilardi, E. A.; Vitaku, E.; Njardarson, J. T. “An In-Pharm-ative Educational Poster Anthology Highlighting the Therapeutic Agents that Chronicle Our Medicinal History” J. Chem. Ed. 2013, 90, 1403-1405.
58) Njardarson, J. T.; Batory, L.; Bricacheck, M.; Bauer, R.; Rogers, E. “Production of 2,5-Dihydrofurans and Analogous Compounds” US Patent 8404872 issued March 26th 2013.
57) Njardarson, J. T. “Catalytic Ring Expansion Adventures” Synlett 2013, 787-803.
56) Mack, D. J.; Njardarson, J. T. “Recent Advances in the Metal Catalyzed Ring Expansions of Three and Four Membered Rings” ACS Catalysis 2013, 3, 272-286.
55) Mack, D. J.; Njardarson, J. T. “Syntheses and Structural Confirmations of Members of a Heterocycle Containing Family of Labdane Diterpenoids” Angew. Chem. Int. Ed. 2013, 52, 1543-1547.
54) Mustard, T. J. L.;Mack, D. J.; Njardarson, J. T.; Cheong, P. H.-Y. “Mechanism and the Origins of Stereospecificity in Copper Catalyzed Ring Expansion of Vinyl Oxiranes: A Traceless Dual Transition Metal-Mediated Process” J. Am. Chem. Soc. 2013, 134, 1471-1475.
53) Mack, D. J.; Njardarson, J. T. “New Mechanistic Insights into the Copper Catalyzed Ring Expansion of Vinyl Aziridines: Evidence in Support of a Copper(I) Mediated Pathway” Chem. Sci. 2012, 3, 3321-3325.
52) Njardarson, J. T. “Reactions at Your Fingertips” Nature Chem. 2012, 4, 590-590.
51) Mack, D. J.; Isoe, J.; Miesfeld, R. L.; Njardarson, J. T. “Distinct Biological Effects of Golgicide A Derivatives on Larval and Adult Mosquitoes” Bioorg. Med. Chem. Lett. 2012, 22, 5177-5181.
50) Mack, D. J.; Guo, B.; Njardarson, J. T. “Synthesis of Allylic and Homoallylic Alcohols from Unsaturated Cyclic Ethers Using a Mild and Selective C-O Reduction Approach” Chem. Commun. 2012, 48,7844-7846.
49) Draghici, C.; Njardarson, J. T. “Chemistry By Design – A Web Based Educational Flashcard for Exploring Synthetic Organic Chemistry” J. Chem. Ed. 2012, 89, 1080-1082.
48) Guo, B.; Schwarzwalder, G.; Njardarson, J. T. “Catalytic Ring Expansion of Vinyl Oxetanes. Asymmetric Synthesis of Dihydropyrans Using Chiral Counterion Catalysis” Angew. Chem. Int. Ed. 2012, 51, 5675-5678.
47) Njardarson, J. T. “Pharmaceutical Structure Montages as Catalysts for Design and Discovery” Future Med. Chem. 2012, 4, 951-954.
46) Mack, D. J.; Batory, L. A.; Njardarson, J. T. “Intermolecular Oxonium Ylide Mediated Synthesis of Medium Sized Oxacycles” Org. Lett. 2012, 14, 378-381.
45) Li, F.; Calabrese, D.; Brichacek, M.; Lin, I.; Njardarson, J. T. “Efficient Synthesis of Thiopyrans Using Sulfur Enabled Anionic Cascade” Angew. Chem. Int. Ed. 2012, 51, 1938-1941.
44) Njardarson, J. T. “Synthetic Efforts Toward [3.3.1] Bridged Bicyclic Phloroglucinol Natural Products” Tetrahedron 2011, 67, 7631-7666.
43) Brichacek, M.; Navarro Villalobos, M.; Plichta, A.; Njardarson J. T. “Stereospecific Ring Expansion of Chiral Vinyl Aziridines” Org. Lett. 2011, 13, 1110-1113.
42) McGrath, N. A.; Binner, J. R.; Markopoulos, G.; Brichacek, M.; Njardarson J. T. “An Efficient Oxidative Dearomatization-Radical Cyclization Approach to Symmetrically Substituted Bicyclic Guttiferone Natural Products” Chem. Commun. 2011, 47, 209-211.
41) Brichacek, M.; Batory, L. A.; McGrath, N. A.; Njardarson J. T. “The Strategic Marriage of Method and Motif. Total Synthesis of Varitriol” Tetrahedron 2010, 66, 4832-4840.
40) McGrath, N. A.; Brichacek, M.; Njardarson J. T. “A Graphical Journey of Innovative Organic Architectures That Have Improved Our Lives” J. Chem. Ed. 2010, 87, 1348-1349.
39) Brichacek, M.; Batory, L. A.; Njardarson, J. T. “A Stereoselective Ring Expansion of Vinyl Oxiranes. Mechanistic Insights and Natural Product Total Synthesis” Angew. Chem. Int. Ed. 2010, 49, 1648-1651.
38) McGrath, N. A.; Bartlett, E. S.; Sittihan, S.; Njardarson, J. T. “A Concise Ring Expansion Route to the Compact Core of Platensimycin” Angew. Chem. Int. Ed. 2009, 48, 8543-8546.
37) Morton, J. G. M.; Dragichi, C.; Kwon, L. D.; Njardarson, J. T. “Rapid Assembly of Vinigrol’s Unique Carbocyclic Skeleton” Org. Lett. 2009, 11, 4492-4495.
36) Brichacek, M.; Njardarson, J. T. “Creative Approaches Towards the Synthesis of 2,5-Dihydro- Furans, Thiophenes and Pyrroles. One Method Does Not Fit All!” Org. Biomol. Chem. 2009, 7, 1761-1770.
35) Morton, J. G. M.; Kwon, L. D.; Freeman, J. D.; Njardarson, J. T. “Efforts Towards the Total Synthesis of Vinigrol” Synlett 2009, 23-27.
34) Morton, J. G. M.; Kwon, L. D.; Freeman, J. D.; Njardarson, J. T. “An Adler Oxidation Approach to Vinigrol” Tetrahedron Lett. 2009, 50, 1684-1686.
33) McGrath, N.; Lee, C. A.; Araki, H.; Brichacek, M.; Njardarson, J. T. “An Efficient Substrate Controlled Synthesis of Hypoestoxide, a Member of a Unique Family of Diterpenoid Natural Products with an Inside-Out [9.3.1]Bicyclic Core” Angew. Chem. Int. Ed. 2008, 47, 9450-9453.
32) Brichacek, M.; Njardarson, J. T.; Lee, D.-E. “Lewis Acid Catalyzed [1,3]-Sigmatropic Rearrangement of Vinyl Aziridines” Org. Lett. 2008, 10, 5023-5026.
31) Njardarson, J. T.; Batory, L.; Bricachek, M.; Bauer, R.; Rogers, E. “Process for the Preparation of 2,5-Dihydrofuran Derivatives” WO2007108999 issued September 27th 2007.
30) Scheinberg, D.; McDewitt, M.; Antczak, C.; Chattopadhyay, D.; May, R.; Njardarson, J. T.; Phillips, M. D. “Single Wall Carbon Nanotube Constructs for Targeting Tumors” WO2007016466 issued February 8th 2007.
29) McDewitt, M. R.; Chattopadhyay, D.; Jaggi, J. S.; Finn, R. D.; Zanzonico, P. B.; Villa, C.; Rey, D.; Mendenhall, J.; Batt, C. A.; Njardarson, J. T.; Scheinberg, D. A. “PET Imaging of Soluble Yttrium-86-Labeled Carbon Nanotubes in Mice” PLoS One 2007, 2, e907.
28) McDewitt, M. R.; Chattopadhyay, D.; Kappel, B. J.; Jaggi, J. S.; Schiffman, S. R; Antczak, C.; Njardarson, J. T.; Scheinberg, D. A. “Tumor Targeting with Antibody-Functionalized, Radiolabeled Carbon Nanotubes” J. Nuc. Med. 2007, 48, 1180-1189.
27) Rogers, E.; Araki, H.; Batory, L. A.; McInnis, C. E.; Njardarson, J. T. “Highly Selective Copper-Catalyzed Ring Expansion of Vinyl Thiiranes: Application to Synthesis of Biotin and the Heterocyclic Core of Plavix” J. Am. Chem. Soc. 2007, 129, 2768-2769.
26) Batory, L. A.; McInnis, C. E.; Njardarson, J. T. “Copper Catalyzed Rearrangement of Vinyl Oxiranes” J. Am. Chem. Soc. 2006, 128, 16054-16055.
Undergraduate, Graduate and Post-doctoral Publications:
25) Leung, J. C.; Bedermann, A. B.; Njardarson, J. T.; Spiegel, D. A.; Murphy, G. K.; Hama, N.; Twenter, B. M.; Dong, P.; Shirahata, T.; McDonald, I. M.; Inoue, M.; Taniguchi, N.; McMahon, T. C.; Schneider, C. M.; Tao, N.; Stoltz, B. M.; Wood, J. L. “Total Synthesis of Phomoidride D” Angew. Chem. Int. Ed. 2018, 57, 1991-1994.
24) Danishefsky, S. J.; Gaul, C.; Njardarson, J. T.; Moore, M. A. S.; Wu, K.; Dorn, D. C.; Mandal, M. “Migrastatin Analogs in the Treatment of Cancer” US Patent 8957056 issued February 17th 2015.
23) Lecomte, N.; Njardarson, J. T.; Nagorny, P.; Yang, G.; Downey, R. J.; Ouerfelli, O.; Moore, M. A. S.; Danishefsky, S. J. “Emergence of Potent Inhibitors of Metastasis in Lung Cancer via Syntheses Based on Migrastatin” Proc. Natl. Acad. Sci. U. S. A. 2011, 108, 15074-15078.
22) Danishefsky, S. J.; Gaul, C.; Njardarson, J. T. “Migrastatin Analogs and Uses Thereof” US Patent 7943800 issued May 17th 2011.
21) Nagorny, P.; Krauss, I.; Njardarson, J. T.; Perez, L.; Gaul, G.; Yang, G.; Ouerfelli, O.; Danishefsky, S. J. “Confirmation of the Structure of Synthetic Derivatives of Migrastatin in the Light of Recently Disclosed Crystallographically Based Claims” Tetrahedron Lett. 2010, 51, 3873-3875.
20) Danishefsky, S. J.; Gaul, C.; Njardarson, J. T.; Moore, M. A. S.; Wu, K.; Dorn, D. C.; Mandal, M. “Preparation of Migrastatin and its Analogs for use in Pharmaceutical Compositions for the Treatment of Cancer” WO2006001967 issued January 5th 2006.
19) Shan, D.; Chen, L.; Njardarson, J. T.; Gaul, C.; Ma, X.; Danishefsky, S. J.; Huang, X.-Y. “Synthetic Analogues of Migrastatin That Inhibit Mammary Tumor Metastasis in Mice” Proc. Natl. Acad. Sci. U. S. A. 2005, 102, 3772-3776.
18) Gaul, C.; Njardarson, J. T.; Shan, D.; Dorn, D. C.; Wu, K.-D.; Tong, W. P.; Huang, X.-Y.; Moore, M. A.; Danishefsky, S. J. “The Migrastatin Family: Discovery of Promising Tumor Cell Migration Inhibitors by Chemical Synthesis” J. Am. Chem. Soc. 2004, 126, 11326-11337.
17) Njardarson, J. T.’ Gaul, C.; Shan, D.; Huang, X.-Y.; Danishefsky, S. J. “Discovery of Potent Cell Migration Inhibitors through Total Synthesis: Lessons from Structure-Activity Studies of (+)-Migrastatin” J. Am. Chem. Soc. 2004, 126, 1038-1040.
16) Huang, X.-D.; Danishefsky, S. J.; Gaul, C.; Njardarson J. T. “Preparation of Migrastatin Analogs and Their Biological Activity” WO2004087672 issued October 14th 2004.
15) Danishefsky, S. J.; Gaul, C.; Njardarson J. T. “Preparation of Migrastatin Analogs and Their Biological Activity” WO2004087673 issued October 14th 2004.
14) Wood, J. L.; Graeber, J. K.; Njardarson, J. T. ”Application of Phenolic Oxidation Chemistry in Synthesis: Preparation of the BCE Ring System of Ryanodine” Tetrahedron 2003, 59, 8855-8858.
13) Spiegel, D. A.; Njardarson, J. T.; McDonald, I.; Wood, J. L. “Innovation and Art in Organic Chemistry: Synthetic Efforts toward the Phomoidrides” Chem. Rev. 2003, 103, 2691-2727.
12) Gaul, C.; Njardarson, J. T.; Danishefsky, S. J. “The Total Synthesis of (+)-Migrastatin” J. Am. Chem. Soc. 2003, 125, 6042-6043.
11) Danishefsky, S. J.; Biswas, K.; Chapell, M.; Lin, H.; Njardarson, J. T.; Lee, C.; Rivkin, A.; Chou, T.-C. “Synthesis of Epothilones for Therepeutic Use as Anticancer Agents” WO2003022844 issued March 20th 2003.
10) Njardarson, J. T.; Garbaccio, R. M.; Danishefsky, S. J. “Radicicol and the Epothilones: Total Synthesis of Novel Anti-Cancer Agents Using Ring Closing Metathesis”, in “Handbook of Metathesis” Ed. Grubbs, Robert H.; Wiley, New York, 2003, Chapter 2.9, Appendix 3, p353.
09) Njardarson, J. T.; Biswas, K.; Danishefsky, S. J. “Application of Hitherto Unexplored Macrocyclization Strategies in the Epothilone Series: Novel Epothilone Analogs by Total Synthesis” Chem. Commun. 2002, 2759-2761.
08) Rivkin, A.; Njardarson, J. T.; Biswas, K.; Chou, T-C.; Danishefsky, S. J. “Total Syntheses of [17]- and [18]Dehydrodesoxyepothilones B via a Concise Ring-Closing Metathesis-Based Strategy: Correlation of Ring Size with Biological Activity in the Epothilones Series” J. Org. Chem. 2002, 67, 7737-7740.
07) Biswas, K.; Lin, H.; Njardarson, J. T.; Chappell, M. D.; Chou, T.-C.; Guan, Y.; Tong, W. P.; He, L.; Horwitz, S. B.; Danishefsky, S. J. “Highly Concise Routes to Epothilones: The Total Synthesis and Evaluation of Epothilone 490” J. Am. Chem. Soc. 2002, 124, 9825-9832.
06) Spiegel, D. A.; Njardarson, J. T.; Wood, J. L “CP-263,114 Synthetic Studies. Construction of an Isotwistane Ring System via Rhodium Carbenoid C-H Insertion” Tetrahedron 2002, 58, 6545-6554.
05) Drutu, I.; Njardarson, J. T.; Wood, J. L. “Reactive Dienes: Intramolecular Aromatic Oxidation of 3-(2-Hydroxyphenyl)-propionic Acids” Org. Lett. 2002, 4, 493-496.
04) Njardarson, J. T.; MacDonald, I.; Spiegel, D. A.; Inoue, M.; Wood, J. L. “An Expeditious Approach Towards the Total Synthesis of CP-263,114” Org. Lett. 2001, 3, 2435-2438.
03) Njardarson, J. T.; Wood, J. L. “Evolution of a Synthetic Approach to CP-263,114” Org. Lett. 2001, 3, 2431-2434.
02) Geirsson, J. K. F.; Gudmundsson, B. O.; Johannesdottir, J. F.; Njardarson, J. T.; Skulason, V. “Concise Synthetic Route to Pure Isomers of the Antifungal Agents (E)- and (Z)-1,2- Diaryl-3-(1-imidazolyl)-1-propenes” Acta Chem. Scand. 1995, 49, 423-427.
01) Geirsson, J. K. F.; Njardarson, J. T. “A Facile Synthesis of a-Phosphono Esters through Methoxycarbonylation of a-Phosphono Carbanions” Tetrahedron Lett. 1994, 35, 9071-9072.